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This effect was prevented by co-administration in the CB1 receptor antagonist SR141716a, but not by co-administration on the CB2 receptor antagonist SR144528, suggesting this action of WIN55,212-2 is mediated by way of

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., 1997). It was confirmed this outcome was mediated throughout the CB1 receptor and happened at a dose that was not linked to obvious Unwanted effects. This analyze also demonstrated an increase lionwin55 in thermal hyperalgesia and mechanical allodynia by administration of SR141716a by yourself, leading the authors to infer the presence of an endogenous tone of cannabinoid lionwin55 analgesia in neuropathy. On the other hand, the proof for this kind lionwin55 of tone for the duration of inflammation is controversial (Beaulieu et al